Dihydroquercetin, also known as Taxifolin, is a natural flavonoid compound that is widely present in fruits, vegetables and some trees (such as larch). It has antioxidant, anti-inflammatory and cardiovascular protection effects, and is one of the hot natural active components studied in recent years.

I. Chemical Structure and Source

The chemical structure of dihydroquercetin is similar to that of quercetin, but the double bond at the C2-C3 position is reduced to a single bond, making it more water-soluble and stable. The main natural sources include:

Plants and their primary products: such as grape seeds, onions, citrus fruits, birch bark and other natural plant parts, as well as plant-based beverages like red wine, green tea, and cocoa.

It is mostly achieved through solvent extraction of plant raw materials or through biological synthesis techniques.

II. Biological Activity and Mechanism of Action

Antioxidant effect

By eliminating free radicals and activating antioxidant enzymes (such as superoxide dismutase SOD), it reduces oxidative stress damage and protects cell membranes and DNA.

Anti-inflammatory and immune regulation

Inhibiting the release of inflammatory factors (such as TNF-α, IL-6), regulating the activity of immune cells, and having potential benefits for chronic inflammatory-related diseases (such as arthritis).

Cardiovascular protection

Improves vascular endothelial function, reduces LDL oxidation, prevents atherosclerosis; also inhibits platelet aggregation and reduces the risk of thrombosis.

Metabolic regulation

Promotes sugar and lipid metabolism, improves insulin sensitivity, and may assist in the management of diabetes or obesity.